A recent study indicates that individuals who come off new GLP-1 drugs like Mounjaro or Wegovy tend to recover shed pounds much more quickly than those who end conventional diet and exercise regimens.
Published data in a major health publication demonstrates that while obese people frequently drop a large proportion of their body weight while on the medication, the mass returns at an estimated rate of 0.8 kg per month after stopping.
"People using such treatments must be informed of the risk of rapid weight regain when the medication concludes," stated researcher Dr. Susan Jebb.
That rate of recovery implies a return to original mass within about 18 months.
Comparing Therapies
The analysis, which looked at dozens of trials involving over 9,000 of patients, contrasted the effects of the injectable medications with conventional dieting.
The team emphasize that people who lose weight through diet and exercise typically see a slower weight regain—around 100 grams monthly—once they finish.
The Reason for the Quick Rebound
Experts suggest the way of the jabs is key to understanding the amplified rebound.
The injections imitate a natural hormone called GLP-1, which controls appetite.
"Sustained high doses of the hormone levels far above than normal may cause the body to generate a reduced amount of its own natural GLP-1, and could reduce responsiveness to its effects," said Dr. Adam Collins, a dietetics expert.
"Stopping of this medication leads to hunger is no longer kept in check, making overeating much more probable."
An Ongoing Issue?
Health authorities recommend the injections for individuals with obesity-related medical conditions, accompanied by prescribed lifestyle changes.
Many experts argue that, due to the high risk of relapse, the therapy might need to be life-long.
This opinion is reinforced by drug manufacturers, who note that the results "underscore the chronic nature of obesity," similar to managing diseases like hypertension.
User Accounts
People who have discontinued the jabs report a powerful return of cravings.
"It was like a trigger activating and I was suddenly starving," recalled a patient.
The struggle is worsened if individuals have not developed sustainable lifestyle or habit modifications during therapy.
Widespread Adoption
Figures suggest that a significant number of adults in the UK have tried weight-loss jabs in the past year, with desire continuing to grow.
- Use is higher among women compared to men.
- The 40s and 50s age group shows the highest usage rates.
- Many obtain the drugs through private prescriptions rather than public health services.
Finally, researchers emphasize that while these medications are powerful tools for weight loss, they are not a permanent fix and lasting health benefits likely depends on combined lifestyle management.
